Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA.
| Product Description || May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA. |
| Tested Applications ||WB IF |
| Image || |
| ||Immunofluorescence staining of methanol-fixed Hela cells using S6 Ribosomal Protein (Phospho-Ser235) Antibody #11232.|
| ||Western blot analysis of extracts from PC12 cells untreated or treated with anisomycin using S6 Ribosomal Protein (Phospho-Ser235) Antibody #11232.|
| Species Reactivities ||Human Mouse Rat |
| Immunogen ||Peptide sequence around phosphorylation site of serine 235 (R-L-S(p)-S-L) derived from Human S6 Ribosomal Protein. |
| Storage Instructions ||Store at -20°C |
| Clonality ||Polyclonal Antibody |
- Phosphorylation of ribosomal protein S6 confers PARP inhibitor resistance in BRCA1-deficient cancers. Sun CK, et al. Oncotarget, 2014 May 30. PMID 24831086 Free PMC Article
- Phosphorylated S6 as an immunohistochemical biomarker of vulvar intraepithelial neoplasia. Pinto AP, et al. Mod Pathol, 2013 Nov. PMID 23765247
- Prognostic significance and function of phosphorylated ribosomal protein S6 in esophageal squamous cell carcinoma. Kim SH, et al. Mod Pathol, 2013 Mar. PMID 22996377
- A novel origin for granulovacuolar degeneration in aging and Alzheimer's disease: parallels to stress granules. Castellani RJ, et al. Lab Invest, 2011 Dec. PMID 21968813 Free PMC Article
- pS6 Expression in normal renal parenchyma, primary renal cell carcinomas and their metastases. Hager M, et al. Pathol Oncol Res, 2012 Apr. PMID 21792700
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Lott J.B., Mackie G.A.
Gene 65:31-39(1988) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
- The primary structure of the human ribosomal protein S6 derived from a cloned cDNA.
Heinze H., Arnold H.H., Fischer D., Kruppa J.
J. Biol. Chem. 263:4139-4144(1988) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
- The organization of the intron-containing human S6 ribosomal protein (rpS6) gene and determination of its location at chromosome 9p21.
Antoine M., Fried M.
Hum. Mol. Genet. 1:565-570(1992) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
- The human ribosomal protein S6 gene: isolation, primary structure and location in chromosome 9.
Pata I., Hoth S., Kruppa J., Metspalu A.
Gene 121:387-392(1992) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
- Identification of immuno-peptidmics that are recognized by tumor-reactive CTL generated from TIL of colon cancer patients.
Shichijo S., Itoh K.
Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon adenocarcinoma.