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Anti-Abl (Y253H) Mouse Monoclonal Antibody, 100 µl (26154) Cancer Research NewEast Biosciences NEBA10177
Background V-abl Abelson murine leukemia viral oncogene homolog 1 also known as ABL1, is a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, stress response and cell migration. Deficient in Abl can cause seve..
Anti-Active Arf6 Mouse Monoclonal Antibody, 30 µl (26918) Signal Transduction NewEast Biosciences NEBA10223
Background ARF6 ( ADP- ribosylation factor 6 ) is a member of the ARF superfamily. ARF genes encode small GTPases that increase the ADP- ribosyltransferase activity of cholera toxin and are critical for vesicular trafficking as activators of phospholipase D. Arf6 regulate s membrane trafficki..
Anti-Active Arl1 Mouse Monoclonal Antibody, 30 µl (26924) Signal Transduction NewEast Biosciences NEBA10229
Background Arl1 (Arf-like 1) localizes to the Golgi complex, where it is believed to recruit effector proteins to the trans-Golgi network. Golgi-localized proteins golgin-97 and golgin-245 have been shown as Arl1 effectors. Additional Arl1 effectors include the GARP (Golgi-associated retrograde pro..
Anti-Active Arl3 Mouse Monoclonal Antibody, 30 µl (26925) Signal Transduction NewEast Biosciences NEBA10230
Background Arl3 (Arf-like 3) is an Arf family protein. Arl3 binds microtubules to alter specific aspects of cytokinesis. It has been proposed that retinitis pigmentosa 2 functions in concert with Arl3 to link the cell membrane and the cytoskeleton in photoreceptors as part of the cell signaling or ..
Anti-Active Cdc42 Mouse Monoclonal Antibody, 30 µl (26905) Signal Transduction NewEast Biosciences NEBA10212
Background Small GTPases are a superfamily of cellular signaling regulators. Cdc42 belongs to the Rho sub-family of GTPases that regulate cell motility, cell division, and gene transcription. GTP binding increases the activity of Cdc42, and the hydrolysis of GTP to GDP renders it inactive. GTP hydr..
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Anti-Active Gα13-GTP Mouse Monoclonal Antibody, 30 µl (26902) Signal Transduction NewEast Biosciences NEBA10209
Background Heterotrimeric G proteins are essential cellular signal transducers. Gα13 is one of the G proteins that could mediate cell migration and angiogenesis. Other biochemical and physiological functions of Gα13 are being explored. Tested Applications IP, IHC Source Species Mouse Species R..
Anti-Active Gαi Mouse Monoclonal Antibody, 30 µl (26901) Signal Transduction NewEast Biosciences NEBA10208
Background Heterotrimeric G proteins are critical cellular signal transducers. Gαi represents one sub-family of G proteins that could mediate the inhibition of adenylyl cyclases. Other biochemical and physiological functions of Gαi proteins are being explored. Tested Applications IP, IHC Sour..
Anti-Active Gαo Mouse Monoclonal Antibody, 30 µl (26907) Signal Transduction NewEast Biosciences NEBA10214
Background Heterotrimeric G proteins are critical cellular signal transducers. Gαo represents one sub-family of G proteins that could mediate the inhibition of adenylyl cyclases. Other biochemical and physiological functions of Gαo proteins are being explored. Tested Applications IP, IHC Source ..
Anti-Active Gαs Mouse Monoclonal Antibody, 30 µl (26906) Signal Transduction NewEast Biosciences NEBA10213
Background Heterotrimeric G proteins are critical cellular signal transducers. Gαs represents one sub-family of G proteins that could mediate the stimulation of adenylyl cyclases. Tested Applications IP, IHC Source Species Mouse Species Reactivity Anti-active Gαs antibody recognizes active Gα..
Anti-Active Gαz Mouse Monoclonal Antibody, 30 µl (26908) Signal Transduction NewEast Biosciences NEBA10215
Background Heterotrimeric G proteins are critical cellular signal transducers. Gαz represents one sub-family of G proteins that could mediate the inhibition of adenylyl cyclases. Other biochemical and physiological functions of Gαz proteins are being explored. Tested Applications IP, IHC Source ..
Anti-Active Rab11 Mouse Monoclonal Antibody, 30 µl (26919) Signal Transduction NewEast Biosciences NEBA10224
Background Small GTPases of the Rab- family are crucial elements of the machinery that controls membrane traffic. Rab11 has been shown to control traffic through the recycling endosome. Tested Applications IP, IHC Source Species Mouse Species Reactivity Anti-active Rab11 antibody recogniz..
Anti-Active Rab3 Mouse Monoclonal Antibody, 30 µl (26920) Signal Transduction NewEast Biosciences NEBA10225
Background Rab3 is a member of the Rab-family GTPases and is specifically targeted to synaptic vesicles. Tested Applications IP, IHC, IF Source Species Mouse Species Reactivity Anti-active Rab3 antibody recognizes active Rab3 proteins of vertebrates. Datasheet   Immunoprecipitatio..
Anti-Active Rab35 Mouse Monoclonal Antibody, 30 µl (26922) Signal Transduction NewEast Biosciences NEBA10227
Background The Rab family of GTPases regulates eukaryotic vesicular membrane traffic. Rab35 is with both plasma membrane and endosomal localization, and has been implicated in diverse processes that include T-cell receptor recycling, oocyte yolk protein recycling and cytokinesis. Rab35 regulates ne..
Anti-Active Rab4 Mouse Monoclonal Antibody, 30 µl (26921) Signal Transduction NewEast Biosciences NEBA10226
Background Rab-4 belongs to the small GTPase Rab family. It interacts with RAB11FIP1, RABEP1, ZFYVE20, RUFY1, SGSM1, SGSM2 and SGSM3. It participates in protein transport and in vesicular traffic. Tested Applications IP, IHC Source Species Mouse Species Reactivity Anti-active Rab4 antibody re..
Anti-Active Rab5 Mouse Monoclonal Antibody, 30 µl (26911) Signal Transduction NewEast Biosciences NEBA10218
Background Rab5 is a member of Rab-family GTPases. Rab5 is a rate-limiting component of the machinery regulating the kinetics of membrane traffic in the early endocytic pathway. Tested Applications IP, IHC Source Species Mouse Species Reactivity Anti-active Rab5 antibody recognizes active Rab..
Anti-Active Rab7 Mouse Monoclonal Antibody, 30 µl (26923) Signal Transduction NewEast Biosciences NEBA10228
Background Rab7 belongs to the Rab family of small GTPases. Rab7 is located in the late endosome, lysosome, cytoplasmic vesicle, phagosome and melanosome. It is involved in the late endocytic transport and contributes to the maturation of phagosomes. Tested Applications IP, IHC, IF Source Specie..
Anti-Active Rac-GTP Mouse Monoclonal Antibody, 30 µl (26903) Signal Transduction NewEast Biosciences NEBA10210
Background Small GTPases are a superfamily of cellular signaling regulators. Rac belongs to the Rho sub-family of GTPases that regulate cell motility, cell division, and gene transcription. GTP binding increases the activity of Rac, and the hydrolysis of GTP to GDP renders it inactive.Currently the..
Anti-Active Ral Mouse Monoclonal Antibody, 30 µl (26913) Signal Transduction NewEast Biosciences NEBA10220
Background The Ras- like small G proteins, RalA and RalB, are important components of Ras signaling pathways, implicated in the initiation and m aintenance of tumorigenic transformation, as well as vesicle transport, apoptosis, transcription, cell migration, and cell proliferation. Tested App..
Anti-Active Ran Mouse Monoclonal Antibody, 30 µl (26915) Signal Transduction NewEast Biosciences NEBA10221
Background Ran (Ras-related nuclear protein) is a member of the Ras-superfamily GTPases. Ran is invovled in the transport of proteins across the nuclear envelope, as well as in microtubule organization during mitosis. Tested Applications IP, IHC Source Species Mouse Species Reactivity Anti-ac..
Anti-Active Rap1 Mouse Monoclonal Antibody, 30 µl (26912) Signal Transduction NewEast Biosciences NEBA10219
Background Small GTPases are a superfamily of cellular signaling regulators. Rap family members (Rap1A, Rap1B, Rap2A, Rap2B, and Rap2C) are Ras-like GTPases that regulate cell proliferation, differentiation, apoptosis and adhesion mechanisms. Rap1 (Ras-proximate-1) regulates apoptosis through inter..
Anti-Active Ras Mouse Monoclonal Antibody, 30 µl (26909) Signal Transduction NewEast Biosciences NEBA10216
Background Small GTPases are a superfamily of cellular signaling regulators. Ras belongs to the Ras sub-family of GTPases that regulate cell proliferation, cell motility, and gene transcription. GTP binding increases the activity of Ras, and the hydrolysis of GTP to GDP renders it inactive. GTP hyd..
Anti-Active Rheb Mouse Monoclonal Antibody, 30 µl (26910) Signal Transduction NewEast Biosciences NEBA10217
Background Small GTPases are a superfamily of cellular signaling regulators. Rheb is a member of the Ras-superfamily GTPases. Rheb has been shown to interact with C-Raf, Mammalian target of rapamycin (mTOR), TSC2, Ataxia telangiectasia mutated (ATM), KIAA1303 and Ataxia telangiectasia and Rad3 rela..
Anti-Active RhoA Mouse Monoclonal Antibody, 30 µl (26904) Signal Transduction NewEast Biosciences NEBA10211
Background Small GTPases are a superfamily of cellular signaling regulators. RhoA belongs to the Rho sub-family of GTPases. Rho proteins play critical roles in many actin cytoskeleton- dependent processes including platelet aggregation, cell motility, contraction, and cytokinesis. It regulates the ..
Anti-Active Sar1 Mouse Monoclonal Antibody, 30 µl (26916) Signal Transduction NewEast Biosciences NEBA10222
Background Small GTPases are a superfamily of cellular signaling regulators. Sar1 is a member of these small GTPases. Sar1 functions as a molecular switch to control protein–protein and protein–lipid interactions that direct vesicle budding from the ER. Tested Applications IP, IHC Source Sp..
Anti-AKT1 (E49K) Mouse Monoclonal Antibody, 100 µl (26137) Cancer Research NewEast Biosciences NEBA10170
Background AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinases, which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. Its function is mediated through serine and/or threonine phosphorylat..
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