Tyrosine Hydroxylase (Phospho-Ser19) Rabbit Polyclonal Antibody, 100 ug DBOA15296

Tyrosine Hydroxylase (Phospho-Ser19) Rabbit Polyclonal Antibody, 100 ug Applications DBio DBOA15296
Tyrosine Hydroxylase (Phospho-Ser19) Rabbit Polyclonal Antibody, 100 ug Applications DBio DBOA15296
Supplier: DBio
Product Code: DBOA15296
Availability: In Stock

Background:

catalyzes the rate limiting step in catecholamine biosynthesis; may be involved in response to hypoxia [RGD, Feb 2006]

Product datasheet:

Overview

Product Description   The protein encoded by Tyrosine Hydroxylase is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Tested Applications IF
Image
Immunofluorescence staining of methanol-fixed Hela cells using Tyrosine Hydroxylase (Phospho-Ser19) Antibody #11329.
Species Reactivities Human Rat
Immunogen Peptide sequence around phosphorylation site of serine19 (A-V-S(p)-E-Q) derived from Rat Tyrosine Hydroxylase (TH).

Properties

Storage Instructions Store at -20°C
Clonality Polyclonal Antibody

References:

  1. HYSCORE Analysis of the Effects of Substrates on Coordination of Water to the Active Site Iron in Tyrosine Hydroxylase. McCracken J, et al. Biochemistry, 2015 Jun 23. PMID 26024204
  2. Molecular basis of chronic stress-induced hippocampal lateral asymmetry in rats and impact on learning and memory. Spasojevic N, et al. Acta Physiol Hung, 2013 Dec. PMID 24317346
  3. Neurobiological consequences of acute footshock stress: effects on tyrosine hydroxylase phosphorylation and activation in the rat brain and adrenal medulla. Ong LK, et al. J Neurochem, 2014 Feb. PMID 24117713
  4. Mutagenesis of a specificity-determining residue in tyrosine hydroxylase establishes that the enzyme is a robust phenylalanine hydroxylase but a fragile tyrosine hydroxylase. Daubner SC, et al. Biochemistry, 2013 Feb 26. PMID 23368961 Free PMC Article
  5. Males, but not females, lose tyrosine hydroxylase fibers in the medial prefrontal cortex and are impaired on a delayed alternation task during aging. Chisholm NC, et al. Behav Brain Res, 2013 Apr 15. PMID 23327742 Free PMC Article
General
NCBI Gene ID 25085
Weight 55-60
Applications IF
Component Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration 1.0mg/mL
Size 100 ug
Source Species Rabbit
Protein
Synonym The
Antibody
Specificity The antibody detects endogenous level of TyrosineHydroxylase only when phosphorylated at serine19.
Immunogen Peptide sequence around phosphorylation site of serine19 (A-V-S(p)-E-Q) derived from Rat Tyrosine Hydroxylase (TH).
Clonality Polyclonal
Storage Instructions Store at -20°C
Species Reactivity Human Rat

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